Authors |
Awad O, Dedkov EI, Jiao C, Bloomer S, Tomanek RJ, Schatteman GC |
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Title |
Differential healing activities of CD34+ and CD14+ endothelial cell progenitors |
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Full source | Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):758-64 | |
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Abstract |
OBJECTIVE:
Peripheral blood contains primitive (stem cell-like) and monocytic-like
endothelial cell progenitors. Diabetes apparently converts these primitive
progenitors, from a pro-angiogenic to anti-angiogenic phenotype. Monocytic
progenitors seem to be less affected by diabetes, but potential pro-angiogenic
activities of freshly isolated monocytic progenitors remain unexplored.
We compared the ability of primitive and monocytic endothelial cell progenitors
to stimulate vascular growth and healing in diabetes and investigated
potential molecular mechanisms through which the cells mediate their in
vivo effects.
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